Antrafenine is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in...
Monday, December 26, 2011
Monday, December 26, 2011
Antipyrine
Antipyrine is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-...
Monday, December 26, 2011
Antazoline
Antazoline binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief...
Monday, December 26, 2011
Anisotropine Methylbromide
Quaternary ammonium compounds such as anisotropine methylbromide inhibit the muscarinic actions of acetylcholine on structures innervated b...
Monday, December 26, 2011
Anisindione
Like phenindione, to which it is related chemically, anisindione exercises its therapeutic action by reducing the prothrombin activity of ...
Monday, December 26, 2011
Anileridine
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G...
Monday, December 26, 2011
Anidulafungin
Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibits glucan synthase, an enzyme present in funga...
Monday, December 26, 2011
Anastrozole
Anastrozole selectively inhibits aromatase. The principal source of circulating estrogen (primarily estradiol) is conversion of adrenally-...
Monday, December 26, 2011
Anagrelide
The mechanism by which anagrelide reduces blood platelet count is still under investigation. Studies in patients support a hypothesis of d...
Monday, December 26, 2011
Amyl Nitrite
Amyl nitrite's antianginal action is thought to be the result of a reduction in systemic and pulmonary arterial pressure (afterload) an...
Monday, December 26, 2011
Amsacrine
Amsacrine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two ...
Monday, December 26, 2011
Amrinone
Amrinone is a phosphodiesterase inhibitor (PDE3), resulting in increased cAMP and cGMP which leads to an increase in the calcium influx lik...
Monday, December 26, 2011
Amprenavir
Amprenavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immatu...
Monday, December 26, 2011
Ampicillin
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last st...
Monday, December 26, 2011
Amphotericin B
Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. T...
Monday, December 26, 2011
Amphetamine
Amphetamines stimulate the release of norepinephrine from central adrenergic receptors. At higher dosages, they cause release of dopamine ...
Monday, December 26, 2011
Amoxicillin
Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sen...
Monday, December 26, 2011
Monday, December 26, 2011
Amodiaquine
The mechanism of plasmodicidal action of amodiaquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit ...
Monday, December 26, 2011
Amobarbital
Amobarbital (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding si...
Monday, December 26, 2011
Amlodipine
Amlodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through ...
Monday, December 26, 2011
Amlexanox
As a benzopyrano-bipyridine carboxylic acid derivative, amlexanox has anti-inflammatory and antiallergic properties. It inhibits chemical ...
Monday, December 26, 2011
Amitriptyline
Amitriptyline is metabolized to nortriptyline which inhibits the reuptake of norepinephrine and serotonin almost equally. Amitriptyline in...
Monday, December 26, 2011
Amisulpride
Amisulpride binds selectively to dopamine D(2) and D(3) receptors in the limbic system. Low doses of amisulpride preferentially block pres...
Monday, December 26, 2011
Amiodarone
The antiarrhythmic effect of amiodarone may be due to at least two major actions. It prolongs the myocardial cell-action potential (phase 3...
Monday, December 26, 2011
Aminosalicylic Acid
There are two mechanisms responsible for aminosalicylic acid's bacteriostatic action against Mycobacterium tuberculosis . Firstly, amin...
Monday, December 26, 2011
Aminophylline
Theophylline is structurally related to theobromine and caffeine. The precise mechanism of action of theophylline is not known, however, it...
Monday, December 26, 2011
Aminophenazone
Aminophenazone is metabolized very slowly by normal newborn babies. In older infants, a higher amount of exhaled 13-CO2 is observed.
Monday, December 26, 2011
Aminolevulinic acid
According to the presumed mechanism of action, photosensitization following application of aminolevulinic acid (ALA) topical solution occu...
Monday, December 26, 2011
Aminohippurate
Aminohippurate is filtered by the renal glomeruli and secreted into the urine by the proximal tubules. By measuring the amount of drug in t...
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