Mechanism action of Butorphanol
The exact mechanism of action is unknown, but is believed to interact
with an opiate receptor site in the CNS (probably in or associated with
the limbic system). The opiate antagonistic effect may result from
competitive inhibition at the opiate receptor, but may also be a result
of other mechanisms. Butorphanol is a mixed agonist-antagonist that
exerts antagonistic or partially antagonistic effects at mu opiate
receptor sites, but is thought to exert its agonistic effects
principally at the kappa and sigma opiate receptors.
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