Mechanism action of Bacitracin
Bacitracin intereferes with the dephosphorylation of the 55-carbon,
biphosphate lipid transport molecule C55-isoprenyl pyrophosphate
(undecaprenyl pyrophosphate), which carries the building blocks of the
peptidoglycan bacterial cell wall outside the inner membrane for
construction. Bacitracin binds divalent transition metal ions (Mn(II),
Co(II), Ni(II), Cu(II), and Zn(II)) which binds and oxidatively cleave
DNA.
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