Mechanism action of Bleomycin
Although the exact mechanism of action of bleomycin is unknown,
available evidence would seem to indicate that the main mode of action
is the inhibition of DNA synthesis with some evidence of lesser
inhibition of RNA and protein synthesis. DNA cleavage by bleomycin
depends on oxygen and metal ions, at least in vitro. It is believed that
bleomycin chelates metal ions (primarily iron) producing a
pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide
free radicals that cleave DNA.
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