Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects muscle relaxation, an...
Alpha-Linolenic Acid
Alpha Linolenic Acid or ALA is considered an essential fatty acid because it is required for human health, but cannot be synthesized by hu...
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Almotriptan
Almotriptan binds with high affinity to human 5-HT 1B and 5-HT 1D receptors leading to cranial blood vessel constriction.
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Allylestrenol
Allylestrenol is similar in structure and function to progesterone. Progesterone shares the pharmacological actions of the progestins. Pro...
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Allopurinol
Allopurinol and its active metabolite, oxypurinol, inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxant...
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Alizapride
The anti-emetic action of Alizapride is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone (CTZ) in the centr...
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Alitretinoin
Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activ...
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Alfentanil
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G...
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Alfacalcidol
The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed by the 25-hydroxylase in the liver and th...
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Alendronate
The action of Alendronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. ...
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Alclometasone
The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to ac...
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Alcaftadine
Alcaftadine is a H1 histamine receptor antagonist and inhibitor of the release of histamine from mast cells. Decreased chemotaxis and inhi...
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Albendazole
Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site o...
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Adinazolam
Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effec...
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Adenosine triphosphate
ATP is able to store and transport chemical energy within cells. ATP also plays an important role in the synthesis of nucleic acids. ATP ca...
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Adenosine monophosphate
Nucleotides such as Adenosine-5'-Monophosphate affect a number of immune functions, including the reversal of malnutrition and starvat...
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Adefovir Dipivoxil
Adefovir dipivoxil is a prodrug of adefovir. Adefovir is an acyclic nucleotide analog of adenosine monophosphate which is phosphorylated to...
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Acetylsalicylic acid
The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to actions by both the acetyl and the salicylate...
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Acetyldigitoxin
Acetyldigitoxin binds to a site on the extracellular aspect of the α-subunit of the Na + /K + ATPase pump in the membranes of heart cells ...
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Acetylcysteine
Acetylcysteine may protect against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glu...
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Acetophenazine
Acetophenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hyp...
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Acetohydroxamic Acid
Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in uri...
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Acetohexamide
Sulfonylureas such as acetohexamide bind to an ATP-dependent K + channel on the cell membrane of pancreatic beta cells. This inhibits a t...
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Acetazolamide
The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon di...
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Acetaminophen
Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, ...
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Aceprometazine
Aceprometazine, acting as an H1-receptor antagonist can induce sedation by being able to cross the blood-brain-barrier and binding to H1-r...
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Acepromazine
Acepromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 a...
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Acenocoumarol
Acenocoumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofact...
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Acebutolol
Acebutolol is a selective β1-receptor antagonist. Activation of β1-receptors by epinephrine increases the heart rate and the blood pressur...
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Acamprosate
The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypo...
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