Mechanism action of Carbamazepine
Carbamazepine inhibits sustained repetitive firing by blocking
use-dependent sodium channels. Pain relief is believed to be associated
with blockade of synaptic transmission in the trigeminal nucleus and
seizure control with reduction of post-tetanic potentiation of synaptic
transmission in the spinal cord. Carbamazepine also possesses
anticholinergic, central antidiuretic, antiarrhythmic, muscle relaxant,
antidepressant (possibly through blockade of norepinephrine release),
sedative, and neuromuscular-blocking properties.
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