Mechanism action of Butenafine
Although the mechanism of action has not been fully established, it has
been suggested that butenafine, like allylamines, interferes with
sterol biosynthesis (especially ergosterol) by inhibiting squalene
monooxygenase, an enzyme responsible for converting squalene to
2,3-oxydo squalene. As ergosterol is an essential component of the
fungal cell membrane, inhibition of its synthesis results in increased
cellular permeability causing leakage of cellular contents. Blockage of
squalene monooxygenase also leads to a subsequent accumulation of
squalene. When a high concentration of squalene is reached, it is
thought to have an effect of directly kill fungal cells.
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