Mechanism action of Buspirone
Buspirone binds to 5-HT type 1A serotonin receptors on presynaptic
neurons in the dorsal raphe and on postsynaptic neurons in the
hippocampus, thus inhibiting the firing rate of 5-HT-containing neurons
in the dorsal raphe. Buspirone also binds at dopamine type 2 (DA2)
receptors, blocking presynaptic dopamine receptors. Buspirone increases
firing in the locus ceruleus, an area of brain where norepinephrine cell
bodies are found in high concentration. The net result of buspirone
actions is that serotonergic activity is suppressed while noradrenergic
and dopaminergic cell firing is enhanced.
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