Mechanism action of Carphenazine
A yellow, powdered, phenothiazine antipsychotic agent used in the
treatment of acute or chronic schizophrenia. The term "phenothiazines"
is used to describe the largest of the five main classes of neuroleptic
antipsychotic drugs. These drugs have antipsychotic and, often,
antiemetic properties, although they may also cause severe side effects
such as akathisia, tardive dyskinesia and extrapyramidal symptoms.
Carphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2
receptors in the brain; depresses the release of hypothalamic and
hypophyseal hormones and is believed to depress the reticular activating
system thus affecting basal metabolism, body temperature, wakefulness,
vasomotor tone, and emesis.
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