Mechanism action of Bopindolol
Bopindolol (as pindolol) non-selectively blocks beta-1 adrenergic
receptors mainly in the heart, inhibiting the effects of epinephrine and
norepinephrine resulting in a decrease in heart rate and blood
pressure. By binding beta-2 receptors in the juxtaglomerular apparatus,
Pindolol inhibits the production of renin, thereby inhibiting
angiotensin II and aldosterone production and therefore inhibits the
vasoconstriction and water retention due to angiotensin II and
aldosterone, respectively.
No comments:
Post a Comment