Mechanism action of Beclometasone dipropionate
Unbound corticosteroids cross cell membranes and bind with high affinity
to specific cytoplasmic receptors. The result includes inhibition of
leukocyte infiltration at the site of inflammation, interference in the
function of mediators of inflammatory response, suppression of humoral
immune responses, and reduction in edema or scar tissue. The
antiinflammatory actions of corticosteroids are thought to involve
phospholipase A2 inhibitory proteins, lipocortins, which control the
biosynthesis of potent mediators of inflammation such as prostaglandins
and leukotrienes.
For the investigated use in the treatment of GvHD or Crohn's,
beclometasone acts by binding to interleukin-13 to inhibit cytokines,
which in turn inhibits inflammatory chemicals downstream.
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