Mechanism action of Benzylpenicilloyl Polylysine
The skin test for penicillin demonstrates the presence or absence of
specific IgE antibodies to major and minor penicillin determinants. IgE
antibodies to major determinants can be detected by using
benzylpenicilloyl polylysine. A penicillin skin test predicts only the
presence of IgE antibodies for the major or minor penicillin
determinants at the time of application and does not predict the future
development of IgE-mediated reactions during subsequent courses of
penicillin. Benzylpenicilloyl polylysine reacts specifically with
penicilloyl skin sensitizing antibodies (reagins) to produce immediate
wheal and flare reactions which may reflect increased risk of allergic
reactions to subsequent penicillin therapy.
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