Mechanism action of Bifonazole
Bifonazole works by inhibiting the production of a substance called
ergosterol, which is an essential component of fungal cell membranes.It
acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as
Lanosterol 14-alpha demethylase). This is vital in the cell membrance
structure of the fungus. Its inhibition leads to cell lysis. The
disruption in production of ergosterol disrupts the cell membrane and
causes holes to appear. The cell membranes of fungi are vital for their
survival. They keep unwanted substances from entering the cells and stop
the contents of the cells from leaking out. As bifonazole causes holes
to appear in the cell membranes, essential constituents of the fungal
cells can leak out. This kills the fungi.
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