Mechanism action of Balsalazide
The mechanism of action of 5-aminosalicylic acid is unknown, but appears
exert its anti-inflammatory effects locally (in the GI tract) rather
than systemically. Mucosal production of arachidonic acid metabolites,
both through the cyclooxygenase pathways (catalyzes the formation of
prostaglandin precursors from arachidonic acid), and through the
lipoxygenase pathways (catalyzes the formation of leukotrienes and
hydroxyeicosatetraenoic acids from arachidonic acid and its
metabolites), is increased in patients with chronic inflammatory bowel
disease. Therefore, it is possible that 5-aminosalicylic acid diminishes
inflammation by blocking production of arachidonic acid metabolites in
the colon through both the inhibition of cyclooxygenase and
lipoxygenase.
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