Mechanism action of Bismuth Subsalicylate
As an antidiarrheal, the exact mechanism has not been determined.
Bismuth subsalicylate may exert its antidiarrheal action not only by
stimulating absorption of fluid and electrolytes across the intestinal
wall (antisecretory action) but also, when hydrolyzed to salicylic acid,
by inhibiting synthesis of a prostaglandin responsible for intestinal
inflammation and hypermotility. In addition, bismuth subsalicylate binds
toxins produced by Escherichia coli. Both bismuth subsalicylate and the
intestinal reaction products, bismuth oxychloride and bismuth
hydroxide, are believed to have bactericidal action. As an antacid,
bismuth has weak antacid properties.
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