Mechanism action of Carboplatin
Alkylating agents work by three different mechanisms: 1) attachment of
alkyl groups to DNA bases, resulting in the DNA being fragmented by
repair enzymes in their attempts to replace the alkylated bases,
preventing DNA synthesis and RNA transcription from the affected DNA, 2)
DNA damage via the formation of cross-links (bonds between atoms in the
DNA) which prevents DNA from being separated for synthesis or
transcription, and 3) the induction of mispairing of the nucleotides
leading to mutations.
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