Mechanism action of Buclizine
Vomiting (emesis) is essentially a protective mechanism for removing
irritant or otherwise harmful substances from the upper GI tract. Emesis
or vomiting is controlled by the vomiting centre in the medulla region
of the brain, an important part of which is the chemotrigger zone (CTZ).
The vomiting centre possesses neurons which are rich in muscarinic
cholinergic and histamine containing synapses. These types of neurons
are especially involved in transmission from the vestibular apparatus to
the vomiting centre. Motion sickness principally involves
overstimulation of these pathways due to various sensory stimuli. Hence
the action of buclizine which acts to block the histamine receptors in
the vomiting centre and thus reduce activity along these pathways.
Furthermore since buclizine possesses anti-cholinergic properties as
well, the muscarinic receptors are similarly blocked.
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