Mechanism action of Candesartan
Candesartan selectively blocks the binding of angiotensin II to AT1 in
many tissues including vascular smooth muscle and the adrenal glands.
This inhibits the AT1-mediated vasoconstrictive and
aldosterone-secreting effects of angiotensin II and results in an
overall decrease in blood pressure. Candesartan is greater than 10,000
times more selective for AT1 than AT2. Inhibition of aldosterone
secretion may increase sodium and water excretion while decreasing
potassium excretion.
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