Mechanism action of Carbenicillin
Free carbenicillin is the predominant pharmacologically active fraction
of the salt. Carbenicillin exerts its antibacterial activity by
interference with final cell wall synthesis of susceptible bacteria.
Penicillins acylate the penicillin-sensitive transpeptidase C-terminal
domain by opening the lactam ring. This inactivation of the enzyme
prevents the formation of a cross-link of two linear peptidoglycan
strands, inhibiting the third and last stage of bacterial cell wall
synthesis. Cell lysis is then mediated by bacterial cell wall autolytic
enzymes such as autolysins; it is possible that carbenicillin interferes
with an autolysin inhibitor.
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