Mechanism action of Brinzolamide
Brinzolamide is a highly specific inhibitor of CA-II, which is the main
CA isoenzyme involved in the secretion of aqueous humor. Inhibition of
CA in the ciliary process of the eye slows the formation of bicarbonate,
and reduces sodium and fluid transport. This results in a reduction in
the rate of aqueous humor secretion and the intraocular pressure.
Brinzolamide is absorbed systemically following topical ocular
administration. Since it has a high affinity for CA-II, brinzolamide
binds extensively to red blood cells, where CA-II is primarily found. As
sufficient CA-II activity remains, adverse effects resulting from the
systemic inhibition of CA by brinzolamide are not observed. The
metabolite N-desethyl brinzolamide is also formed. This metabolite binds
to CA and accumulates in red blood cells as well. In the presence of
brinzolamide, the metabolite binds mainly to carbonic anhydrase I
(CA-I).
Brinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Brinzolamide
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