Mechanism action of Candicidin
Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is
the target site of action of Candicidin. Candicidin binds irreversibly
to ergosterol, resulting in disruption of membrane integrity and
ultimately cell death. There is some evidence that the binding site in
the cell wall may be to fatty acids or fatty acid esters and that this
binding capacity must be satisfied before candicidin can bring about its
lethal effect by binding to sterol in the cell membrane.
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