Mechanism action of Bupropion
Bupropion selectively inhibits the neuronal reuptake of dopamine,
norepinephrine, and serotonin; actions on dopaminergic systems are more
significant than imipramine or amitriptyline whereas the blockade of
norepinephrine and serotonin reuptake at the neuronal membrane is weaker
for bupropion than for tricyclic antidepressants. The increase in
norepinephrine may attenuate nicotine withdrawal symptoms and the
increase in dopamine at neuronal sites may reduce nicotine cravings and
the urge to smoke. Bupropion exhibits moderate anticholinergic effects.
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