Mechanism action of Betamethasone
Betamethasone is a glucocorticoid receptor agonist. This leads to
changes in genetic expression once this complex binds to the GRE. The
antiinflammatory actions of corticosteroids are thought to involve
lipocortins, phospholipase A2 inhibitory proteins which, through
inhibition arachidonic acid, control the biosynthesis of prostaglandins
and leukotrienes. The immune system is suppressed by corticosteroids due
to a decrease in the function of the lymphatic system, a reduction in
immunoglobulin and complement concentrations, the precipitation of
lymphocytopenia, and interference with antigen-antibody binding.
Betamethasone binds to plasma transcortin, and it becomes active when it
is not bound to transcortin.
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